A person in desperate circumstances or who is at the point of desperation, such as a down-and-outer, addict, etc.
In dire need of something.
Being filled with, or in a state of despair; hopeless.
Without regard to danger or safety; reckless; furious.
Beyond hope; causing despair; extremely perilous; irretrievable.
Extreme, in a bad sense; outrageous.
Extremely intense.